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产品目录

Nicastrin/NCSTN抗体图片
产品货号:
Z21625
中文名称:
Nicastrin/NCSTN抗体
英文名称:
Anti-Nicastrin/NCSTN Antibody
产品规格:
50μl|100μl|150μl
发货周期:
1~3天
产品价格:
询价
抗体名称Anti-Nicastrin/NCSTN Antibody
指标别名APH2;KIAA0253;NCSTN;nicastrin
克隆性Polyclonal
检验物种human,mouse,rat
应用范围WB,ICC/IF,ELISA
基因名称NCSTN
抗体来源Rabbit
抗体类型IgG
免疫原E.coli-derived human Nicastrin/NCSTN recombinant protein (Position:N34-E669).
实际分子量120KD/140KD
成分500μg/mL antibody with PBS,0.02% NaN3,1mg BSA and 50% glycerol.
纯化方式Immunogen affinity purified.
浓度500μg/mL
产品形态溶液
保存条件12 months from date of receipt,-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing.
背景资料Nicastrin,also known as?NCSTN,is a?protein?that is a part of the gamma secretase?protein complex.It is mapped to 1q23.2.This gene is not catalytically active,but instead promotes the maturation and proper trafficking of the other proteins in the gamma secretase?protein complex,all of which undergo significant post-translational modification?before becoming active in the cell.NCSTN encodes a Type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex.?The encoded protein cleaves integral membrane proteins,including Notch receptors and beta-amyloid precursor protein,and may be a stabilizing cofactor required for gamma-secretase complex assembly.?The cleavage of beta-amyloid precursor protein yields amyloid beta peptide,the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease.Nicastrin has also been identified as a regulator of neprilysin,an?enzyme?involved in the degradation of amyloid beta fragment.
Uniprot IDQ92542
推荐配套试剂Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot.
基因名全称nicastrin
蛋白名全称Nicastrin
推荐稀释比
Western blot(WB) 1:500~2000
Immunocytochemistry/Immunofluorescence (ICC/IF) 1:50~400
ELISA 1:100~1000

相关搜索:Nicastrin/NCSTN抗体Nicastrin抗体NCSTN多抗Anti-Nicastrin/NCSTN Antibody
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